Bone Abstracts

The circadian clock network is an evolutionally conserved system by which organisms adapt their metabolic activities to the environmental inputs including the availability of nutrients. The master pacemaker of circadian clock system is located in the suprachiasmatic nucleus (SCN) and is well known to play pivotal roles in metabolic regulations including skeletal and mineral metabolisms. In addition to the central pacemaker, peripheral tissues also possess its own circadian sys...

Objectives: As osteoblasts mature, they acquire the expression of multiple molecules involved in phosphate metabolism, including dentin matrix protein 1 (DMP1) and fibroblast growth factor 23 (FGF23). This suggests that osteoblasts and osteocytes may sense and respond to alterations in the phosphate availability in their microenvironment. We previously reported that increased extracellular inorganic phosphate (Pi) triggered signal transduction in various cell types to alter ge...

Background: Hypophosphatasia (HPP) is caused by inactivating mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). HPP is variable in clinical manifestations and prognosis, and is generally classified into six subtypes: perinatal lethal, perinatal benign (prenatal benign), infantile, childhood, adult, and odonto HPP. Although genetic test is broadly used for diagnosis of HPP, the genotype-phenotype relationship still remains unclear.<p class...